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Chemical structure of Asciminib hydrochloride

GC64462

Asciminib hydrochloride

Also known as N-[4-[chloro(difluoro)methoxy]phenyl]-6-[(3R)-3-hydroxypyrrolidin-1-yl]-5-(1H-pyrazol-5-yl)pyridine-3-carboxamide;hydrochloride

Asciminib (ABL001) hydrochloride is a potent and selective allosteric BCR-ABL1 inhibitor, which inhibits Ba/F3 cells grown with an IC50 of 0·25 nM

ChemicalCAS2119669-71-3MW486.3FormulaC20H19Cl2F2N5O3
CAS number
2119669-71-3
Molecular weight
486.3
Formula
C20H19Cl2F2N5O3
InChIKey
HGCOOPLEWPBLOY-PFEQFJNWSA-N
Catalogue number
GC64462
Brand
GLPBIO
Computed properties PubChem CID 133082086 · TPSA 103 Ų · H-bond donors 4 · H-bond acceptors 8
TPSA
103 Ų
H-bond donors
4
H-bond acceptors
8
Rotatable bonds
6
Heavy atoms
32

SMILES C1CN(C[C@@H]1O)C2=C(C=C(C=N2)C(=O)NC3=CC=C(C=C3)OC(F)(F)Cl)C4=CC=NN4.Cl

Computed descriptors from PubChem (CID 133082086), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.