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Chemical structure of Englerin A

GC64459

Englerin A

Also known as [(1S,2R,5R,6R,7S,8R,10R)-10-(2-hydroxyacetyl)oxy-1,5-dimethyl-8-propan-2-yl-11-oxatricyclo[6.2.1.02,6]undecan-7-yl] (E)-3-phenylprop-2-enoate

Englerin A is a potent and selective activator of TRPC4 and TRPC5 channels, with EC50s of 11·2 and 7·6 nM, respectively· Englerin A can induce renal carcinoma cells death by elevated Ca2+ influx and Ca2+ cell overload

ChemicalCAS1094250-15-3MW442.54FormulaC26H34O6
CAS number
1094250-15-3
Molecular weight
442.54
Formula
C26H34O6
InChIKey
GACOFEKSDCOVMV-RRYXBOBMSA-N
Catalogue number
GC64459
Brand
GLPBIO
Computed properties PubChem CID 46242512 · XLogP 4.8 · TPSA 82.1 Ų · H-bond donors 1
XLogP
4.8
TPSA
82.1 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
8
Heavy atoms
32

SMILES C[C@@H]1CC[C@@H]2[C@@H]1[C@@H]([C@@]3(C[C@H]([C@]2(O3)C)OC(=O)CO)C(C)C)OC(=O)/C=C/C4=CC=CC=C4

Computed descriptors from PubChem (CID 46242512), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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