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Chemical structure of Almonertinib mesylate

GC64398

Almonertinib mesylate

Also known as N-[5-[[4-(1-cyclopropylindol-3-yl)pyrimidin-2-yl]amino]-2-[2-(dimethylamino)ethyl-methylamino]-4-methoxyphenyl]prop-2-enamide;methanesulfonic acid

Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations· Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0·37, 0·29 and 0·21 nM, respectively), and is less effective against wild type (3·39 nM)· Almonertinib mesylate is used for the research of the non-small cell lung cancer

ChemicalCAS2134096-06-1MW621.75FormulaC31H39N7O5S
CAS number
2134096-06-1
Molecular weight
621.75
Formula
C31H39N7O5S
Solubility
DMSO ： 31·25 mg/mL (50·26 mM; ultrasonic and warming and heat to 60°C)
InChIKey
WTEXJDGTVUQRQY-UHFFFAOYSA-N
Catalogue number
GC64398
Brand
GLPBIO
Computed properties PubChem CID 162368359 · TPSA 150 Ų · H-bond donors 3 · H-bond acceptors 10
TPSA
150 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
11
Heavy atoms
44

SMILES CN(C)CCN(C)C1=CC(=C(C=C1NC(=O)C=C)NC2=NC=CC(=N2)C3=CN(C4=CC=CC=C43)C5CC5)OC.CS(=O)(=O)O

Computed descriptors from PubChem (CID 162368359), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.