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Chemical structure of Valproic acid-d6

GC64378

Valproic acid-d6

Also known as 5,5,5-trideuterio-2-(3,3,3-trideuteriopropyl)pentanoic acid

Valproic acid-d6 (VPA-d6) is the deuterium labeled Valproic acid· Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0·5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2· Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells· Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches

ChemicalCAS87745-18-4MW150.25FormulaC8H10D6O2
CAS number
87745-18-4
Molecular weight
150.25
Formula
C8H10D6O2
InChIKey
NIJJYAXOARWZEE-WFGJKAKNSA-N
Catalogue number
GC64378
Brand
GLPBIO
Computed properties PubChem CID 159148 · XLogP 2.8 · TPSA 37.3 Ų · H-bond donors 1
XLogP
2.8
TPSA
37.3 Ų
H-bond donors
1
H-bond acceptors
2
Rotatable bonds
5
Heavy atoms
10

SMILES [2H]C([2H])([2H])CCC(CCC([2H])([2H])[2H])C(=O)O

Computed descriptors from PubChem (CID 159148), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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