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Chemical structure of DI-87

GC64342

DI-87

Also known as 2-[(1R)-1-[2-[4-methoxy-3-(2-morpholin-4-ylethoxy)phenyl]-5-methyl-1,3-thiazol-4-yl]ethyl]sulfanylpyrimidine-4,6-diamine

DI-87 is an orally active and selective deoxycytidine kinase (dCK) inhibitor with an EC50 of 10·2 nM· DI-87 has antitumor activity and is used in combination therapy against tumors expressing dCK

ChemicalCAS2107280-55-5MW502.65FormulaC23H30N6O3S2
CAS number
2107280-55-5
Molecular weight
502.65
Formula
C23H30N6O3S2
InChIKey
MFVINMPRHHUSBW-OAHLLOKOSA-N
Catalogue number
GC64342
Brand
GLPBIO
Computed properties PubChem CID 122491414 · XLogP 3 · TPSA 175 Ų · H-bond donors 2
XLogP
3
TPSA
175 Ų
H-bond donors
2
H-bond acceptors
11
Rotatable bonds
9
Heavy atoms
34

SMILES CC1=C(N=C(S1)C2=CC(=C(C=C2)OC)OCCN3CCOCC3)[C@@H](C)SC4=NC(=CC(=N4)N)N

Computed descriptors from PubChem (CID 122491414), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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