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Chemical structure of Vevorisertib trihydrochloride

GC64231

Vevorisertib trihydrochloride

Also known as N-[1-[3-[3-[4-(1-aminocyclobutyl)phenyl]-2-(2-amino-3-pyridinyl)imidazo[4,5-b]pyridin-5-yl]phenyl]piperidin-4-yl]-N-methylacetamide;trihydrochloride

Vevorisertib (ARQ 751) trihydrochloride is a selective, allosteric, pan-AKT and AKT1-E17K mutant inhibitors· Vevorisertib trihydrochloride potently inhibit phosphorylation of AKT· Vevorisertib trihydrochloride has Kd values of 1·2 nM and 8·6 nM for AKT1 and AKT1-E17K, respectively· Vevorisertib trihydrochloride has IC50 values of 0·55, 0·81, and 1·3 nM for AKT1, AKT2, and AKT3, respectively· Vevorisertib trihydrochloride can be used for the research of cancer

ChemicalCAS1416775-08-0MW696.11FormulaC35H41Cl3N8O
CAS number
1416775-08-0
Molecular weight
696.11
Formula
C35H41Cl3N8O
Solubility
DMSO ： 150 mg/mL (215·48 mM; Need ultrasonic)
InChIKey
HNFNJTGXAZHZSB-UHFFFAOYSA-N
Catalogue number
GC64231
Brand
GLPBIO
Computed properties PubChem CID 131746460 · TPSA 119 Ų · H-bond donors 5 · H-bond acceptors 7
TPSA
119 Ų
H-bond donors
5
H-bond acceptors
7
Rotatable bonds
6
Heavy atoms
47

SMILES CC(=O)N(C)C1CCN(CC1)C2=CC=CC(=C2)C3=NC4=C(C=C3)N=C(N4C5=CC=C(C=C5)C6(CCC6)N)C7=C(N=CC=C7)N.Cl.Cl.Cl

Computed descriptors from PubChem (CID 131746460), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.