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Chemical structure of AZD-9574

GC64099

AZD-9574

Also known as 6-fluoro-5-[4-[(5-fluoro-2-methyl-3-oxo-4H-quinoxalin-6-yl)methyl]piperazin-1-yl]-N-methylpyridine-2-carboxamide

AZD-9574 is a potent and brain penetrant PARP1 inhibitor and shows >8000-fold selectivity for PARP1 compared to PARP2/3/5a/6

ChemicalCAS2756333-39-6MW428.44FormulaC21H22F2N6O2
CAS number
2756333-39-6
Molecular weight
428.44
Formula
C21H22F2N6O2
Solubility
DMSO ： 22·22 mg/mL (51·86 mM; ultrasonic and adjust pH to 4 with HCl); DMSO ： 8·33 mg/mL (19·44 mM; ultrasonic and warming and heat to 60°C)
InChIKey
WXRCLFFPZXJCLS-UHFFFAOYSA-N
Catalogue number
GC64099
Brand
GLPBIO
Computed properties PubChem CID 162524593 · XLogP 1.2 · TPSA 89.9 Ų · H-bond donors 2
XLogP
1.2
TPSA
89.9 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
31

SMILES CC1=NC2=C(C(=C(C=C2)CN3CCN(CC3)C4=C(N=C(C=C4)C(=O)NC)F)F)NC1=O

Computed descriptors from PubChem (CID 162524593), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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