Loading...
Chemical structure of Lu AF27139

GC63996

Lu AF27139

Also known as N-[(2S)-2-(4-chlorophenyl)-2-morpholin-4-ylethyl]-2-pyrimidin-2-yl-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide

Lu AF27139 is a potent, selective, and orally active antagonist of P2X7 receptor (IC50s of 12 and 2·4 nM for human and rat, Kis of 22, 54, and 13 nM for mouse, human, and rat, respectively)

ChemicalCAS2097117-06-9MW497.92FormulaC21H19ClF3N5O2S
CAS number
2097117-06-9
Molecular weight
497.92
Formula
C21H19ClF3N5O2S
Solubility
DMSO ： 125 mg/mL (251·04 mM; Need ultrasonic)
InChIKey
FGPQIEDRTXLBES-OAHLLOKOSA-N
Catalogue number
GC63996
Brand
GLPBIO
Computed properties PubChem CID 129099048 · XLogP 3.3 · TPSA 108 Ų · H-bond donors 1
XLogP
3.3
TPSA
108 Ų
H-bond donors
1
H-bond acceptors
10
Rotatable bonds
6
Heavy atoms
33

SMILES C1COCCN1[C@H](CNC(=O)C2=C(N=C(S2)C3=NC=CC=N3)C(F)(F)F)C4=CC=C(C=C4)Cl

Computed descriptors from PubChem (CID 129099048), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.