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Chemical structure of Amsilarotene

GC63932

Amsilarotene

Also known as 4-[[3,5-bis(trimethylsilyl)benzoyl]amino]benzoic acid

Amsilarotene (TAC-101; Am 555S), an orally active synthetic retinoid, has selective affinity for retinoic acid receptor α (RAR-α) binding with Ki of 2·4, 400 nM for RAR-α and RAR-β· Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells· Amsilarotene can be used for the research of cancer

ChemicalCAS125973-56-0MW385.6FormulaC20H27NO3Si2
CAS number
125973-56-0
Molecular weight
385.6
Formula
C20H27NO3Si2
Solubility
DMSO ： 100 mg/mL (259·34 mM; Need ultrasonic)
InChIKey
VVTNSTLJOVCBDL-UHFFFAOYSA-N
Catalogue number
GC63932
Brand
GLPBIO
Computed properties PubChem CID 9800306 · TPSA 66.4 Ų · H-bond donors 2 · H-bond acceptors 3
TPSA
66.4 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
5
Heavy atoms
26

SMILES C[Si](C)(C)C1=CC(=CC(=C1)C(=O)NC2=CC=C(C=C2)C(=O)O)[Si](C)(C)C

Computed descriptors from PubChem (CID 9800306), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.