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Chemical structure of Boc-C16-COOH

GC63924

Boc-C16-COOH

Also known as 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid

Boc-C16-COOH is a non-cleavable?ADC linker?used in the synthesis of antibody-drug conjugates (ADCs)· Boc-C16-COOH is also a alkyl chain-based PROTAC linker?that can be used in the synthesis of PROTACs<su PROTAC KRAS G12C degrader-199·55%PROTAC KRAS G12C degrader-1 is a Cereblon-based KRASG12C degrader, with an IC50 of 414 nM for CRBN· PROTAC KRAS G12C degrader-1 induces CRBN/ KRASG12C dimerization and degrades GFP- KRASG12C in reporter cells

ChemicalCAS843666-40-0MW370.57FormulaC22H42O4
CAS number
843666-40-0
Molecular weight
370.57
Formula
C22H42O4
InChIKey
WDUQJXKBWRNMKI-UHFFFAOYSA-N
Catalogue number
GC63924
Brand
GLPBIO
Computed properties PubChem CID 27282473 · XLogP 7.7 · TPSA 63.6 Ų · H-bond donors 1
XLogP
7.7
TPSA
63.6 Ų
H-bond donors
1
H-bond acceptors
4
Rotatable bonds
19
Heavy atoms
26

SMILES CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O

Computed descriptors from PubChem (CID 27282473), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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