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Chemical structure of (R)-PS210

GC63802

(R)-PS210

Also known as 2-[(1R)-3-oxo-1-phenyl-3-[4-(trifluoromethyl)phenyl]propyl]propanedioic acid

(R)-PS210, the R enantiomer of PS210 (compound 4h-eutomer), is a substrate-selective allosteric activator of PDK1 with an AC50 value of 1·8 μM· (R)-PS210 targets to the PIF-binding pocket of?PDK1· PIF: The protein kinase C-related kinase 2 (PRK2)-interacting fragment

ChemicalCAS1410101-89-1MW380.31FormulaC19H15F3O5
CAS number
1410101-89-1
Molecular weight
380.31
Formula
C19H15F3O5
Solubility
DMSO : 230 mg/mL (604·77 mM; Need ultrasonic)
InChIKey
MLJPLHGJBUWCBA-AWEZNQCLSA-N
Catalogue number
GC63802
Brand
GLPBIO
Computed properties PubChem CID 60196221 · XLogP 3.5 · TPSA 91.7 Ų · H-bond donors 2
XLogP
3.5
TPSA
91.7 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
27

SMILES C1=CC=C(C=C1)[C@H](CC(=O)C2=CC=C(C=C2)C(F)(F)F)C(C(=O)O)C(=O)O

Computed descriptors from PubChem (CID 60196221), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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Documents
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