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Chemical structure of (S)-Sunvozertinib

GC63797

(S)-Sunvozertinib

Also known as N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3S)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

(S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51·2 nM, 51·9 nM, 1 nM, and 21·2 nM, respectively)· (S)-Sunvozertinib also inhibits BTK

ChemicalCAS2370013-49-1MW584.08FormulaC29H35ClFN7O3
CAS number
2370013-49-1
Molecular weight
584.08
Formula
C29H35ClFN7O3
Solubility
DMSO ： 50 mg/mL (85·60 mM; Need ultrasonic)
InChIKey
BTMKEDDEMKKSEF-KRWDZBQOSA-N
Catalogue number
GC63797
Brand
GLPBIO
Computed properties PubChem CID 139377763 · XLogP 5 · TPSA 115 Ų · H-bond donors 4
XLogP
5
TPSA
115 Ų
H-bond donors
4
H-bond acceptors
10
Rotatable bonds
10
Heavy atoms
41

SMILES CC(C)(C1=CC(=C(C=C1NC2=NC(=NC=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CC[C@@H](C4)N(C)C)OC)Cl)F)O

Computed descriptors from PubChem (CID 139377763), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.