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Chemical structure of JB170

GC63707

JB170

Also known as 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-N-[2-[2-[2-[[2-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]oxyacetyl]amino]ethoxy]ethoxy]ethyl]-2-methoxybenzamide

JB170 is a potent and highly specific PROTAC-mediated AURORA-A (Aurora Kinase) degrader (DC50=28 nM) by linking Alisertib, to the Cereblon-binding molecule Thalidomide· JB170 preferentially binds AURORA-A (EC50=193 nM) over AURORA-B (EC50=1·4 ?M)· JB170-mediated S-phase arrest is caused specifically by AURORA-A depletion· JB170 has excellent ability to inhibit non-catalytic function of AURORA-A kinase

ChemicalCAS2705844-82-0MW963.36FormulaC48H44ClFN8O11
CAS number
2705844-82-0
Molecular weight
963.36
Formula
C48H44ClFN8O11
Solubility
DMSO ： 100 mg/mL (103·80 mM; Need ultrasonic)
InChIKey
GYKNPXCQINZRLL-UHFFFAOYSA-N
Catalogue number
GC63707
Brand
GLPBIO
Computed properties PubChem CID 153835264 · XLogP 3.7 · TPSA 238 Ų · H-bond donors 4
XLogP
3.7
TPSA
238 Ų
H-bond donors
4
H-bond acceptors
16
Rotatable bonds
19
Heavy atoms
69

SMILES COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)NCCOCCOCCNC(=O)COC6=CC=CC7=C6C(=O)N(C7=O)C8CCC(=O)NC8=O)OC

Computed descriptors from PubChem (CID 153835264), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.