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Chemical structure of Aderbasib

GC63661

Aderbasib

Also known as methyl (6S,7S)-7-(hydroxycarbamoyl)-6-(4-phenylpiperazine-1-carbonyl)-5-azaspiro[2.5]octane-5-carboxylate

Aderbasib (INCB007839) is a potent, orally active and target specific low nanomolar hydroxamate-based inhibitor of ADAM10 and ADAM17· Aderbasib exhibits robust antineoplastic activity and can be used for cancer research, including diffuse large B-cell non-Hodgkin lymphoma, HER2+?breast cancer, gliomas, et al

ChemicalCAS791828-58-5MW416.47FormulaC21H28N4O5
CAS number
791828-58-5
Molecular weight
416.47
Formula
C21H28N4O5
Solubility
DMSO ： 100 mg/mL (240·11 mM; Need ultrasonic)
InChIKey
DJXMSZSZEIKLQZ-IRXDYDNUSA-N
Catalogue number
GC63661
Brand
GLPBIO
Computed properties PubChem CID 16070111 · XLogP 0.8 · TPSA 102 Ų · H-bond donors 2
XLogP
0.8
TPSA
102 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
30

SMILES COC(=O)N1CC2(CC2)C[C@@H]([C@H]1C(=O)N3CCN(CC3)C4=CC=CC=C4)C(=O)NO

Computed descriptors from PubChem (CID 16070111), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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