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Chemical structure of NCGC00029283

GC63653

NCGC00029283

Also known as 3-[5-(4-fluorophenyl)-1,2,4-oxadiazol-3-yl]-6-methoxy-1H-quinolin-2-one

NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC50s of 2·3 μM, 12·5 μM, and 3·4 μM for WRN, BLM and FANCJ helicase, respectively

ChemicalCAS714240-31-0MW337.3FormulaC18H12FN3O3
CAS number
714240-31-0
Molecular weight
337.3
Formula
C18H12FN3O3
InChIKey
FJQADEHMIMENRE-UHFFFAOYSA-N
Catalogue number
GC63653
Brand
GLPBIO
Computed properties PubChem CID 651756 · XLogP 3 · TPSA 77.3 Ų · H-bond donors 1
XLogP
3
TPSA
77.3 Ų
H-bond donors
1
H-bond acceptors
6
Rotatable bonds
3
Heavy atoms
25

SMILES COC1=CC2=C(C=C1)NC(=O)C(=C2)C3=NOC(=N3)C4=CC=C(C=C4)F

Computed descriptors from PubChem (CID 651756), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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