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Chemical structure of CCT128930 hydrochloride

GC63539

CCT128930 hydrochloride

Also known as 4-[(4-chlorophenyl)methyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidin-4-amine;hydrochloride

CCT128930 hydrochloride is a potent and selective inhibitor of AKT (IC50=6 nM)· CCT128930 hydrochloride has 28-fold selectivity over the closely related PKA kinase (IC50=168 nM) through the targeting of Met282 of AKT (Met173 of PKA-AKT chimera), as well as 20-fold selectivity over p70S6K (IC50=120 nM)· CCT128930 hydrochloride induces cell cycle arrest, DNA damage, and autophagy· Antitumor activity

ChemicalCAS2453324-32-6MW378.3FormulaC18H21Cl2N5
CAS number
2453324-32-6
Molecular weight
378.3
Formula
C18H21Cl2N5
InChIKey
OFLOSUNRPFWODP-UHFFFAOYSA-N
Catalogue number
GC63539
Brand
GLPBIO
Computed properties PubChem CID 146013807 · TPSA 70.8 Ų · H-bond donors 3 · H-bond acceptors 4
TPSA
70.8 Ų
H-bond donors
3
H-bond acceptors
4
Rotatable bonds
3
Heavy atoms
25

SMILES C1CN(CCC1(CC2=CC=C(C=C2)Cl)N)C3=NC=NC4=C3C=CN4.Cl

Computed descriptors from PubChem (CID 146013807), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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