GC63528
BET bromodomain inhibitor 1
Also known as 6-[2-(2,4-difluorophenoxy)-5-(ethylsulfonylmethyl)-3-pyridinyl]-8-methyl-2H-pyrrolo[1,2-a]pyrazin-1-one
BET bromodomain inhibitor 1 is an orally active, selective bromodomain and extra-terminal (BET) bromodomain inhibitor with an IC50 of 2·6 nM for BRD4· BET bromodomain inhibitor 1 binds to BRD2(2), BRD3(2), BRD4(1), BRD4(2), and BRDT(2) with high affinities (Kd values of 1·3 nM, 1·0 nM, 3·0 nM, 1·6 nM, 2·1 nM, respectively)· bromodomain inhibitor 1 has anti-cancer activity
ChemicalCAS2411226-02-1MW459.47FormulaC22H19F2N3O4S
- CAS number
- 2411226-02-1
- Molecular weight
- 459.47
- Formula
- C22H19F2N3O4S
- Solubility
- DMSO ： 62·5 mg/mL (136·03 mM; ultrasonic and warming and heat to 60°C)
- InChIKey
- UETQFSCWDMJWMM-UHFFFAOYSA-N
- Catalogue number
- GC63528
- Brand
- GLPBIO
Computed properties PubChem CID 146047136 · XLogP 2.7 · TPSA 98.7 Ų · H-bond donors 1
- XLogP
- 2.7
- TPSA
- 98.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Rotatable bonds
- 6
- Heavy atoms
- 32
SMILES CCS(=O)(=O)CC1=CC(=C(N=C1)OC2=C(C=C(C=C2)F)F)C3=CC(=C4N3C=CNC4=O)C
Computed descriptors from PubChem (CID 146047136), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il