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Chemical structure of Sunvozertinib

GC63521

Sunvozertinib

Also known as N-[5-[[4-[5-chloro-4-fluoro-2-(2-hydroxypropan-2-yl)anilino]pyrimidin-2-yl]amino]-2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]-4-methoxyphenyl]prop-2-enamide

Sunvozertinib (DZD9008) is a potent ErbBs (EGFR, Her2, especially mutant forms) and BTK inhibitor· Sunvozertinib shows IC50s of 20·4, 20·4, 1·1, 7·5, and 80·4 nM for EGFR exon 20 NPH insertion, EGFR exon 20 ASV insertion, EGFR L858R and T790M mutations, and Her2 Exon20 YVMA, and EGFR WT A431, respectively (patent WO2019149164A1, example 52)

ChemicalCAS2370013-12-8MW584.08FormulaC29H35ClFN7O3
CAS number
2370013-12-8
Molecular weight
584.08
Formula
C29H35ClFN7O3
InChIKey
BTMKEDDEMKKSEF-QGZVFWFLSA-N
Catalogue number
GC63521
Brand
GLPBIO
Computed properties PubChem CID 139377809 · XLogP 5 · TPSA 115 Ų · H-bond donors 4
XLogP
5
TPSA
115 Ų
H-bond donors
4
H-bond acceptors
10
Rotatable bonds
10
Heavy atoms
41

SMILES CC(C)(C1=CC(=C(C=C1NC2=NC(=NC=C2)NC3=C(C=C(C(=C3)NC(=O)C=C)N4CC[C@H](C4)N(C)C)OC)Cl)F)O

Computed descriptors from PubChem (CID 139377809), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Documents
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.