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Chemical structure of Aficamten

GC63519

Aficamten

Also known as N-[(1R)-5-(5-ethyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-inden-1-yl]-1-methylpyrazole-4-carboxamide

Aficamten (CK-274) is a potent cardiac myosin inhibitor with an IC50 of 1·4 μM

ChemicalCAS2364554-48-1MW337.38FormulaC18H19N5O2
CAS number
2364554-48-1
Molecular weight
337.38
Formula
C18H19N5O2
Solubility
DMSO ： 125 mg/mL (370·50 mM; Need ultrasonic)
InChIKey
IOVAZWDIRCRMTM-OAHLLOKOSA-N
Catalogue number
GC63519
Brand
GLPBIO
Computed properties PubChem CID 139331495 · XLogP 2.1 · TPSA 85.8 Ų · H-bond donors 1
XLogP
2.1
TPSA
85.8 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
4
Heavy atoms
25

SMILES CCC1=NC(=NO1)C2=CC3=C(C=C2)[C@@H](CC3)NC(=O)C4=CN(N=C4)C

Computed descriptors from PubChem (CID 139331495), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Documents
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