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Chemical structure of Eclitasertib

GC63470

Eclitasertib

Also known as 5-benzyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydropyrido[3,2-b][1,4]oxazepin-3-yl]-1H-1,2,4-triazole-3-carboxamide

Eclitasertib (DNL-758) is a potent receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 of ＜1 ?Μ (From patent WO2017136727A2, example 42)

ChemicalCAS2125450-76-0MW378.38FormulaC19H18N6O3
CAS number
2125450-76-0
Molecular weight
378.38
Formula
C19H18N6O3
Solubility
DMSO ： 125 mg/mL (330·36 mM; Need ultrasonic)
InChIKey
XUZICJHIIJCKQQ-ZDUSSCGKSA-N
Catalogue number
GC63470
Brand
GLPBIO
Computed properties PubChem CID 130298939 · XLogP 1.7 · TPSA 113 Ų · H-bond donors 2
XLogP
1.7
TPSA
113 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
4
Heavy atoms
28

SMILES CN1C(=O)[C@H](COC2=C1N=CC=C2)NC(=O)C3=NNC(=N3)CC4=CC=CC=C4

Computed descriptors from PubChem (CID 130298939), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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