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Chemical structure of Casein Kinase inhibitor A86

GC63463

Casein Kinase inhibitor A86

Also known as 4-N-[4-[5-(cyclopropylmethyl)-1-methylpyrazol-4-yl]-5-fluoropyrimidin-2-yl]cyclohexane-1,4-diamine

Casein Kinase inhibitor A86 is a potent and orally active casein kinase 1α (CK1α) inhibitor· Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb)· Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities

ChemicalCAS2079069-01-3MW344.43FormulaC18H25FN6
CAS number
2079069-01-3
Molecular weight
344.43
Formula
C18H25FN6
Solubility
DMSO ： 12·5 mg/mL (36·29 mM; ultrasonic and warming and heat to 60°C)
InChIKey
YSPIHUWHLMNFOV-UHFFFAOYSA-N
Catalogue number
GC63463
Brand
GLPBIO
Computed properties PubChem CID 134812748 · XLogP 2.4 · TPSA 81.7 Ų · H-bond donors 2
XLogP
2.4
TPSA
81.7 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
25

SMILES CN1C(=C(C=N1)C2=NC(=NC=C2F)NC3CCC(CC3)N)CC4CC4

Computed descriptors from PubChem (CID 134812748), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.