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Chemical structure of CYH33 methanesulfonate

GC63391

CYH33 methanesulfonate

Also known as methanesulfonic acid;methyl N-[5-[6-[(4-methylsulfonylpiperazin-1-yl)methyl]-4-morpholin-4-ylpyrrolo[2,1-f][1,2,4]triazin-2-yl]-4-(trifluoromethyl)-2-pyridinyl]carbamate

CYH33 methanesulfonate is an orally active, highly selective PI3Kα inhibitor with IC50s of 5·9 nM/598 nM/78·7 nM/225 nM against α/β/δ/γ isoform, respectively· CYH33 methanesulfonate inhibits phosphorylation of Akt, ERK and induces significant G1 phase arrest in breast cancer cells and non-small cell lung cancer (NSCLC) cells· CYH33 methanesulfonate has potent activity against solid tumors

ChemicalCAS1494684-33-1MW694.7FormulaC25H33F3N8O8S2
CAS number
1494684-33-1
Molecular weight
694.7
Formula
C25H33F3N8O8S2
InChIKey
CYWUJTNXNJVGLY-UHFFFAOYSA-N
Catalogue number
GC63391
Brand
GLPBIO
Computed properties PubChem CID 72550229 · TPSA 206 Ų · H-bond donors 2 · H-bond acceptors 17
TPSA
206 Ų
H-bond donors
2
H-bond acceptors
17
Rotatable bonds
7
Heavy atoms
46

SMILES COC(=O)NC1=NC=C(C(=C1)C(F)(F)F)C2=NN3C=C(C=C3C(=N2)N4CCOCC4)CN5CCN(CC5)S(=O)(=O)C.CS(=O)(=O)O

Computed descriptors from PubChem (CID 72550229), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.