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Chemical structure of Bcl-xL antagonist 2

GC63325

Bcl-xL antagonist 2

Also known as 2-[8-(1,3-benzothiazol-2-ylcarbamoyl)-3,4-dihydro-1H-isoquinolin-2-yl]-1,3-thiazole-4-carboxylic acid

Bcl-xL antagonist 2 is a potent, selective, and orally active antagonist of BCL-XL with an IC50 and Ki of 0·091 μM and 65 nM, respectively· Bcl-xL antagonist 2 promotes the apoptosis of cancer cells· Bcl-xL antagonist 2 has the potential for the research of the chronic lymphocytic leukemia (CLL) and non-Hodgkin’s lymphoma (NHL)

ChemicalCAS1235032-75-3MW436.51FormulaC21H16N4O3S2
CAS number
1235032-75-3
Molecular weight
436.51
Formula
C21H16N4O3S2
Solubility
DMSO ： 62·5 mg/mL (143·18 mM; Need ultrasonic)
InChIKey
PHCCZZHEZZPUGG-UHFFFAOYSA-N
Catalogue number
GC63325
Brand
GLPBIO
Computed properties PubChem CID 46836567 · XLogP 4.4 · TPSA 152 Ų · H-bond donors 2
XLogP
4.4
TPSA
152 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
4
Heavy atoms
30

SMILES C1CN(CC2=C1C=CC=C2C(=O)NC3=NC4=CC=CC=C4S3)C5=NC(=CS5)C(=O)O

Computed descriptors from PubChem (CID 46836567), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.