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Chemical structure of Xevinapant hydrochloride

GC63290

Xevinapant hydrochloride

Also known as (5S,8S,10aR)-N-benzhydryl-5-[[(2S)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide;hydrochloride

Xevinapant (AT-406) hydrochloride is a potent and orally bioavailable Smac mimetic and an antagonist of the inhibitor of apoptosis proteins (IAPs)· Xevinapant hydrochloride binds to XIAP, cIAP1, and cIAP2 proteins with Kis of 66·4, 1·9, and 5·1 nM, respectively· Xevinapant hydrochloride effectively antagonizes XIAP BIR3 protein in a cell-free functional assay, induces rapid degradation of cellular cIAP1 protein, and inhibits cancer cell growth in various human cancer cell lines· Xevinapant hydrochloride is highly effective in induction of apoptosis in xenograft tumors

ChemicalCAS1071992-57-8MW598.18FormulaC32H44ClN5O4
CAS number
1071992-57-8
Molecular weight
598.18
Formula
C32H44ClN5O4
Solubility
DMSO ： 175 mg/mL (292·55 mM; Need ultrasonic)
InChIKey
DBXTZCYPHKJCHF-ZZPLZQMBSA-N
Catalogue number
GC63290
Brand
GLPBIO
Computed properties PubChem CID 25022339 · TPSA 111 Ų · H-bond donors 4 · H-bond acceptors 5
TPSA
111 Ų
H-bond donors
4
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
42

SMILES C[C@@H](C(=O)N[C@H]1CN(CC[C@H]2CC[C@H](N2C1=O)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4)C(=O)CC(C)C)NC.Cl

Computed descriptors from PubChem (CID 25022339), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.