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Chemical structure of XPC-6444

GC63261

XPC-6444

Also known as 4-[[2-[[tert-butyl(methyl)amino]methyl]-6-fluorophenyl]methylamino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide

XPC-6444 is a highly potent, isoform-selective, and CNS-penetrant NaV1·6 inhibitor (IC50=41 nM for hNaV1·6)

ChemicalCAS2230144-21-3MW498.58FormulaC22H25F3N4O2S2
CAS number
2230144-21-3
Molecular weight
498.58
Formula
C22H25F3N4O2S2
Solubility
DMSO ： 125 mg/mL (250·71 mM; Need ultrasonic)
InChIKey
VOJFVKGTRNXOTJ-UHFFFAOYSA-N
Catalogue number
GC63261
Brand
GLPBIO
Computed properties PubChem CID 134585831 · XLogP 4.4 · TPSA 111 Ų · H-bond donors 2
XLogP
4.4
TPSA
111 Ų
H-bond donors
2
H-bond acceptors
10
Rotatable bonds
9
Heavy atoms
33

SMILES CC(C)(C)N(C)CC1=C(C(=CC=C1)F)CNC2=CC(=C(C(=C2)F)S(=O)(=O)NC3=CSC=N3)F

Computed descriptors from PubChem (CID 134585831), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.