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Chemical structure of Tolebrutinib

GC63232

Tolebrutinib

Also known as 4-amino-3-(4-phenoxyphenyl)-1-[(3R)-1-prop-2-enoylpiperidin-3-yl]imidazo[4,5-c]pyridin-2-one

Tolebrutinib (SAR442168) is a potent, selective, orally active and brain-penetrant inhibitor of Bruton tyrosine kinase (BTK), with IC50s of 0·4 and 0·7 nM in Ramos B cells and in HMC microglia cells, respectively

ChemicalCAS1971920-73-6MW455.51FormulaC26H25N5O3
CAS number
1971920-73-6
Molecular weight
455.51
Formula
C26H25N5O3
Solubility
DMSO ： 100 mg/mL (219·53 mM; Need ultrasonic)
InChIKey
KOEUOFPEZFUWRF-LJQANCHMSA-N
Catalogue number
GC63232
Brand
GLPBIO
Computed properties PubChem CID 124111565 · XLogP 3.2 · TPSA 92 Ų · H-bond donors 1
XLogP
3.2
TPSA
92 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
5
Heavy atoms
34

SMILES C=CC(=O)N1CCC[C@H](C1)N2C3=C(C(=NC=C3)N)N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5

Computed descriptors from PubChem (CID 124111565), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.