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Chemical structure of Tesirine

GC63216

Tesirine

Also known as [4-[[(2S)-2-[[(2S)-2-[3-[2-[2-[2-[2-[2-[2-[2-[2-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (6S,6aS)-3-[5-[[(6aS)-2-methoxy-8-methyl-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-6-hydroxy-2-methoxy-8-methyl-11-oxo-6a,7-dihydro-6H-pyrrolo[2,1-c][1,4]benzodiazepine-5-carboxylate

Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload· Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics· SG3199 is the released warhead component of the ADC payload Tesirine· SG3199 retains picomolar activity in a panel of cancer cell lines· PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity

ChemicalCAS1595275-62-9MW1496.65FormulaC75H101N9O23
CAS number
1595275-62-9
Molecular weight
1496.65
Formula
C75H101N9O23
Solubility
DMSO ： 200 mg/mL (133·63 mM; Need ultrasonic)
InChIKey
HKGATZAPXCCEJR-OWRSNIELSA-N
Catalogue number
GC63216
Brand
GLPBIO
Computed properties PubChem CID 73672523 · XLogP 1.6 · TPSA 367 Ų · H-bond donors 5
XLogP
1.6
TPSA
367 Ų
H-bond donors
5
H-bond acceptors
24
Rotatable bonds
49
Heavy atoms
107

SMILES CC1=CN2[C@@H](C1)C=NC3=CC(=C(C=C3C2=O)OC)OCCCCCOC4=C(C=C5C(=C4)N([C@H]([C@@H]6CC(=CN6C5=O)C)O)C(=O)OCC7=CC=C(C=C7)NC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN8C(=O)C=CC8=O)OC

Computed descriptors from PubChem (CID 73672523), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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