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Chemical structure of PW0464

GC63157

PW0464

Also known as 6-[4-[[3-(difluoromethoxy)-2-pyridinyl]oxy]-2-methylphenyl]-1,5-dimethylpyrimidine-2,4-dione

PW0464, a nanomolar potent complete G protein biased ligand, is a noncatechol D1R agonist, with an EC50 of 5·8 nM (Gs-cAMP)

ChemicalCAS1643462-93-4MW389.35FormulaC19H17F2N3O4
CAS number
1643462-93-4
Molecular weight
389.35
Formula
C19H17F2N3O4
Solubility
DMSO : 25 mg/mL (64·21 mM; ultrasonic and warming and heat to 60°C)
InChIKey
ZXIPVZWZRQCIRW-UHFFFAOYSA-N
Catalogue number
GC63157
Brand
GLPBIO
Computed properties PubChem CID 86764103 · XLogP 3.3 · TPSA 80.8 Ų · H-bond donors 1
XLogP
3.3
TPSA
80.8 Ų
H-bond donors
1
H-bond acceptors
7
Rotatable bonds
5
Heavy atoms
28

SMILES CC1=C(C=CC(=C1)OC2=C(C=CC=N2)OC(F)F)C3=C(C(=O)NC(=O)N3C)C

Computed descriptors from PubChem (CID 86764103), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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