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Chemical structure of BTX161

GC62880

BTX161

Also known as (3S)-3-(7-methyl-3-oxo-1H-isoindol-2-yl)azepane-2,7-dione

BTX161, a Thalidomide analog, is a potent CKIα degrader· BTX161 mediates degradation of CKIα better than Lenalidomide in human AML cells and activates DNA damage response (DDR) and p53, while stabilizing the p53 antagonist MDM2

ChemicalCAS2052301-24-1MW272.3FormulaC15H16N2O3
CAS number
2052301-24-1
Molecular weight
272.3
Formula
C15H16N2O3
InChIKey
CNIZBMYCKRUTHY-LBPRGKRZSA-N
Catalogue number
GC62880
Brand
GLPBIO
Computed properties PubChem CID 124099654 · XLogP 0.9 · TPSA 66.5 Ų · H-bond donors 1
XLogP
0.9
TPSA
66.5 Ų
H-bond donors
1
H-bond acceptors
3
Rotatable bonds
1
Heavy atoms
20

SMILES CC1=C2CN(C(=O)C2=CC=C1)[C@H]3CCCC(=O)NC3=O

Computed descriptors from PubChem (CID 124099654), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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