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Chemical structure of Aldumastat

GC62831

Aldumastat

Also known as (5S)-5-cyclopropyl-5-[3-[(3S)-4-(3,5-difluorophenyl)-3-methylpiperazin-1-yl]-3-oxopropyl]imidazolidine-2,4-dione

Aldumastat (GLPG1972; S201086) is a potent, seletive and orally active ADAMTS-5 (IC50=19 nM) inhibitor, and has 8-fold seletivity over ADAMTS-4 (IC50=156 nM)

ChemicalCAS1957278-93-1MW406.43FormulaC20H24F2N4O3
CAS number
1957278-93-1
Molecular weight
406.43
Formula
C20H24F2N4O3
Solubility
DMSO ： 100 mg/mL (246·04 mM; Need ultrasonic)
InChIKey
CMLVKUWQFZQPPS-YUNKPMOVSA-N
Catalogue number
GC62831
Brand
GLPBIO
Computed properties PubChem CID 121448788 · XLogP 1.6 · TPSA 81.8 Ų · H-bond donors 2
XLogP
1.6
TPSA
81.8 Ų
H-bond donors
2
H-bond acceptors
6
Rotatable bonds
5
Heavy atoms
29

SMILES C[C@H]1CN(CCN1C2=CC(=CC(=C2)F)F)C(=O)CC[C@@]3(C(=O)NC(=O)N3)C4CC4

Computed descriptors from PubChem (CID 121448788), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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