GC62728
(1E)-CFI-400437 dihydrochloride
Also known as 5-methoxy-3-[[3-[(E)-2-[6-(4-methylpiperazin-1-yl)-3-pyridinyl]ethenyl]indazol-6-ylidene]methyl]-1H-indol-2-ol;dihydrochloride
(1E)-CFI-400437 dihydrochloride is a potent PLK4 (IC50= 0·6 nM) inhibitor and selective against other members of the PLK family (>10 μM)· (1E)-CFI-400437 dihydrochloride inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0·37, 0·21, 0·48, and 0·18 μM, respectively· Antiproliferative activity
ChemicalCAS1247000-76-5MW565.49FormulaC29H30Cl2N6O2
- CAS number
- 1247000-76-5
- Molecular weight
- 565.49
- Formula
- C29H30Cl2N6O2
- Solubility
- DMSO ： 12·5 mg/mL (22·10 mM; Need ultrasonic)
- InChIKey
- NYCYUHRNBLSJAP-XPDSEMQYSA-N
- Catalogue number
- GC62728
- Brand
- GLPBIO
Computed properties PubChem CID 136351064 · TPSA 89.3 Ų · H-bond donors 4 · H-bond acceptors 7
- TPSA
- 89.3 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Rotatable bonds
- 5
- Heavy atoms
- 39
SMILES CN1CCN(CC1)C2=NC=C(C=C2)/C=C/C3=C4C=CC(=CC5=C(NC6=C5C=C(C=C6)OC)O)C=C4N=N3.Cl.Cl
Computed descriptors from PubChem (CID 136351064), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.
Ordering in Israel
- Lead time
- Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
- Pricing
- Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
- Documents
- Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
- Who we serve
- Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.
- Questions
- WhatsApp · +972-55-990-7576 · orders@labo.co.il