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Chemical structure of Murizatoclax

GC62707

Murizatoclax

Also known as (3'R,4S,6'R,7'R,8'E,11'S,12'R)-7'-[[(9aR)-1,3,4,6,7,8,9,9a-octahydropyrido[1,2-a]pyrazin-2-yl]methyl]-7-chloro-7'-methoxy-11',12'-dimethyl-13',13'-dioxospiro[2,3-dihydro-1H-naphthalene-4,22'-20-oxa-13lambda6-thia-1,14-diazatetracyclo[14.7.2.03,6.019,24]pentacosa-8,16(25),17,19(24)-tetraene]-15'-one

Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM· Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members· Murizatoclax can be used for the research of cancer

ChemicalCAS2245848-05-7MW765.44FormulaC42H57ClN4O5S
CAS number
2245848-05-7
Molecular weight
765.44
Formula
C42H57ClN4O5S
InChIKey
BJTFTQIBRVBSBH-VCQPVEJUSA-N
Catalogue number
GC62707
Brand
GLPBIO
Computed properties PubChem CID 138669688 · XLogP 7.3 · TPSA 99.8 Ų · H-bond donors 1
XLogP
7.3
TPSA
99.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
3
Heavy atoms
53

SMILES C[C@H]1C/C=C/[C@@]([C@@H]2CC[C@H]2CN3C[C@@]4(CCCC5=C4C=CC(=C5)Cl)COC6=C3C=C(C=C6)C(=O)NS(=O)(=O)[C@@H]1C)(CN7CCN8CCCC[C@@H]8C7)OC

Computed descriptors from PubChem (CID 138669688), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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