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Chemical structure of SCR130

GC62693

SCR130

Also known as 2,4-bis(4-chlorophenyl)-8-sulfanylidene-1,7,9-triazaspiro[4.5]dec-1-ene-6,10-dione

SCR130 is a SCR7-based DNA nonhomologous end-joining (NHEJ) inhibitor· SCR130 inhibits the end-joining of DNA in a Ligase IV-dependent manner· SCR130 is specific to Ligase IV, and shows minimal or no effect on Ligase III and Ligase I mediated joining· SCR130 induces cell apoptosis and has anticancer activity

ChemicalCAS2377858-38-1MW418.3FormulaC19H13Cl2N3O2S
CAS number
2377858-38-1
Molecular weight
418.3
Formula
C19H13Cl2N3O2S
InChIKey
QEMQLCCYJLGAKB-UHFFFAOYSA-N
Catalogue number
GC62693
Brand
GLPBIO
Computed properties PubChem CID 146165950 · XLogP 3.6 · TPSA 103 Ų · H-bond donors 2
XLogP
3.6
TPSA
103 Ų
H-bond donors
2
H-bond acceptors
4
Rotatable bonds
2
Heavy atoms
27

SMILES C1C(C2(C(=O)NC(=S)NC2=O)N=C1C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl

Computed descriptors from PubChem (CID 146165950), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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