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Chemical structure of Thalidomide-NH-PEG3-COOH

GC62681

Thalidomide-NH-PEG3-COOH

Also known as 3-[2-[2-[2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]amino]ethoxy]ethoxy]ethoxy]propanoic acid

Thalidomide-NH-PEG3-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology

ChemicalCAS2375283-62-6MW477.46FormulaC22H27N3O9
CAS number
2375283-62-6
Molecular weight
477.46
Formula
C22H27N3O9
Solubility
DMSO : 125 mg/mL (261·80 mM; Need ultrasonic)
InChIKey
SYFPHSMLSPHFLO-UHFFFAOYSA-N
Catalogue number
GC62681
Brand
GLPBIO
Computed properties PubChem CID 146410740 · XLogP -0.6 · TPSA 161 Ų · H-bond donors 3
XLogP
-0.6
TPSA
161 Ų
H-bond donors
3
H-bond acceptors
10
Rotatable bonds
14
Heavy atoms
34

SMILES C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)NCCOCCOCCOCCC(=O)O

Computed descriptors from PubChem (CID 146410740), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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