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Chemical structure of MRIA9

GC62657

MRIA9

Also known as 8-[(5-amino-1,3-dioxan-2-yl)methyl]-6-[2-chloro-4-(3-fluoro-2-pyridinyl)phenyl]-2-(methylamino)pyrido[2,3-d]pyrimidin-7-one

MRIA9 is an ATP-competitive, pan Salt-Inducible kinase (SIK) and PAK2/3 inhibitor, with IC50 values of 516 nM, 180 nM and 127 nM for SIK1, SIK2 and SIK3, respectively

ChemicalCAS2750707-05-0MW496.92FormulaC24H22ClFN6O3
CAS number
2750707-05-0
Molecular weight
496.92
Formula
C24H22ClFN6O3
InChIKey
QKNBRNSGPNCARD-UHFFFAOYSA-N
Catalogue number
GC62657
Brand
GLPBIO
Computed properties PubChem CID 162642759 · XLogP 2.2 · TPSA 115 Ų · H-bond donors 2
XLogP
2.2
TPSA
115 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
35

SMILES CNC1=NC=C2C=C(C(=O)N(C2=N1)CC3OCC(CO3)N)C4=C(C=C(C=C4)C5=C(C=CC=N5)F)Cl

Computed descriptors from PubChem (CID 162642759), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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