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Chemical structure of bio-THZ1

GC62653

bio-THZ1

Also known as 4-[[(E)-4-[3-[2-[2-[2-[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]ethoxy]ethoxy]ethoxy]ethylcarbamoylamino]propyl-methylamino]but-2-enoyl]amino]-N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]phenyl]benzamide

bio-THZ1 is a biotinylated version of THZ1 and binds irreversibly to CDK7· THZ1 is a selective and potent covalent CDK7 inhibitor with an IC50 of 3·2 nM

ChemicalCAS1604811-14-4MW1053.67FormulaC52H65ClN12O8S
CAS number
1604811-14-4
Molecular weight
1053.67
Formula
C52H65ClN12O8S
Solubility
DMSO ： 120 mg/mL (113·89 mM; Need ultrasonic)
InChIKey
ARPCJVVFIKPHFA-SFDVBDGFSA-N
Catalogue number
GC62653
Brand
GLPBIO
Computed properties PubChem CID 139035075 · XLogP 3.7 · TPSA 279 Ų · H-bond donors 9
XLogP
3.7
TPSA
279 Ų
H-bond donors
9
H-bond acceptors
13
Rotatable bonds
30
Heavy atoms
74

SMILES CN(CCCNC(=O)NCCOCCOCCOCCNC(=O)CCCC[C@H]1[C@@H]2[C@H](CS1)NC(=O)N2)C/C=C/C(=O)NC3=CC=C(C=C3)C(=O)NC4=CC=CC(=C4)NC5=NC=C(C(=N5)C6=CNC7=CC=CC=C76)Cl

Computed descriptors from PubChem (CID 139035075), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.