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Chemical structure of FGFR4-IN-5

GC62602

FGFR4-IN-5

Also known as N-[(3R,4S)-4-[[6-(2,6-dichloro-3,5-dimethoxyphenyl)-8-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]oxolan-3-yl]prop-2-enamide

FGFR4-IN-5 is a potent and selective covalent FGFR4 inhibitor with an IC50 of 6·5 nM· FGFR4-IN-5 exhibits strong anti-tumor activity in vivo and can be used for hepatocellular carcinoma research

ChemicalCAS1628793-01-0MW520.37FormulaC23H23Cl2N5O5
CAS number
1628793-01-0
Molecular weight
520.37
Formula
C23H23Cl2N5O5
Solubility
DMSO ： 100 mg/mL (192·17 mM; Need ultrasonic)
InChIKey
ZIJVLVUPDVUSMA-UONOGXRCSA-N
Catalogue number
GC62602
Brand
GLPBIO
Computed properties PubChem CID 90436886 · XLogP 2.9 · TPSA 115 Ų · H-bond donors 2
XLogP
2.9
TPSA
115 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
35

SMILES CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C(=CC(=C3Cl)OC)OC)Cl)N[C@@H]4COC[C@@H]4NC(=O)C=C

Computed descriptors from PubChem (CID 90436886), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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Pricing
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Documents
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