Loading...
Chemical structure of DS-1205b free base

GC62597

DS-1205b free base

Also known as N-[4-[2-amino-5-[4-[[(2R)-1,4-dioxan-2-yl]methoxy]-3-methoxyphenyl]-3-pyridinyl]-3-fluorophenyl]-5-(5-methyl-2-pyridinyl)-1-(oxan-4-ylmethyl)-4-oxopyridine-3-carboxamide

DS-1205b free base is a potent and selective inhibitor of AXL kinase, with an IC50 of 1·3 nM· DS-1205b free base also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively· DS-1205b free base can inhibit cell migration in vitro and tumor growth in vivo

ChemicalCAS1855860-24-0MW735.8FormulaC41H42FN5O7
CAS number
1855860-24-0
Molecular weight
735.8
Formula
C41H42FN5O7
Solubility
DMSO ： 50 mg/mL (67·95 mM; Need ultrasonic)
InChIKey
ZOEILZXFYPPMTR-SSEXGKCCSA-N
Catalogue number
GC62597
Brand
GLPBIO
Computed properties PubChem CID 129110632 · XLogP 4.3 · TPSA 147 Ų · H-bond donors 2
XLogP
4.3
TPSA
147 Ų
H-bond donors
2
H-bond acceptors
12
Rotatable bonds
11
Heavy atoms
54

SMILES CC1=CN=C(C=C1)C2=CN(C=C(C2=O)C(=O)NC3=CC(=C(C=C3)C4=C(N=CC(=C4)C5=CC(=C(C=C5)OC[C@H]6COCCO6)OC)N)F)CC7CCOCC7

Computed descriptors from PubChem (CID 129110632), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.