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Chemical structure of Difamilast

GC62589

Difamilast

Also known as N-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide

Difamilast (OPA-15406) is a topical, selective and nonsteroidal phosphodiesterase-4 (PDE4) inhibitor with particularly efficient inhibition of subtype B (IC50=11·2 nM)

ChemicalCAS937782-05-3MW446.44FormulaC23H24F2N2O5
CAS number
937782-05-3
Molecular weight
446.44
Formula
C23H24F2N2O5
Solubility
DMSO ： 100 mg/mL (223·99 mM; Need ultrasonic)
InChIKey
VFBILHPIHUPBPZ-UHFFFAOYSA-N
Catalogue number
GC62589
Brand
GLPBIO
Computed properties PubChem CID 57855696 · XLogP 4.8 · TPSA 82.8 Ų · H-bond donors 1
XLogP
4.8
TPSA
82.8 Ų
H-bond donors
1
H-bond acceptors
8
Rotatable bonds
10
Heavy atoms
32

SMILES CCOC1=CC=CC=C1C(=O)NCC2=COC(=N2)C3=CC(=C(C=C3)OC(F)F)OC(C)C

Computed descriptors from PubChem (CID 57855696), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.