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Chemical structure of hSMG-1 inhibitor 11e

GC62572

hSMG-1 inhibitor 11e

Also known as 1-[4-[4-[2-[3-(dimethylsulfamoyl)-4-methylanilino]pyrimidin-4-yl]-2-pyridinyl]phenyl]-3-methylurea

hSMG-1 inhibitor 11e is a potent and selective hSMG-1 kinase inhibitor with an IC50 of 900-fold selectivity over mTOR (IC50 of 45 nM), PI3Kα/γ (IC50s of 61 nM and 92 nM) and CDK1/CDK2 (IC50s of 32 μM and 7·1 μM)

ChemicalCAS1402452-10-1MW517.6FormulaC26H27N7O3S
CAS number
1402452-10-1
Molecular weight
517.6
Formula
C26H27N7O3S
Solubility
DMSO ： 50 mg/mL (96·60 mM; Need ultrasonic)
InChIKey
FOFHDVOENOAIGR-UHFFFAOYSA-N
Catalogue number
GC62572
Brand
GLPBIO
Computed properties PubChem CID 71458574 · XLogP 2.9 · TPSA 138 Ų · H-bond donors 3
XLogP
2.9
TPSA
138 Ų
H-bond donors
3
H-bond acceptors
8
Rotatable bonds
7
Heavy atoms
37

SMILES CC1=C(C=C(C=C1)NC2=NC=CC(=N2)C3=CC(=NC=C3)C4=CC=C(C=C4)NC(=O)NC)S(=O)(=O)N(C)C

Computed descriptors from PubChem (CID 71458574), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
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Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
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Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.