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Chemical structure of LEO 39652

GC62525

LEO 39652

Also known as 2-methylpropyl 1-[8-methoxy-5-(1-oxo-3H-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate

LEO 39652 is a dual-soft PDE4 inhibitor with IC50s of 1·2 nM, 1·2 nM, 3·0 nM and 3·8 nM for PDE4A, PDE4B, PDE4C and PDE4D, respectively

ChemicalCAS1445656-91-6MW421.45FormulaC23H23N3O5
CAS number
1445656-91-6
Molecular weight
421.45
Formula
C23H23N3O5
Solubility
DMSO ： 25 mg/mL (59·32 mM; Need ultrasonic)
InChIKey
LUUUHUYQTLUIDG-UHFFFAOYSA-N
Catalogue number
GC62525
Brand
GLPBIO
Computed properties PubChem CID 71611998 · XLogP 3.3 · TPSA 92 Ų · H-bond donors 0
XLogP
3.3
TPSA
92 Ų
H-bond donors
0
H-bond acceptors
7
Rotatable bonds
7
Heavy atoms
31

SMILES CC(C)COC(=O)C1(CC1)C2=NN3C(=CC=C(C3=N2)OC)C4=CC5=C(C=C4)C(=O)OC5

Computed descriptors from PubChem (CID 71611998), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.