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Chemical structure of Pirtobrutinib

GC62515

Pirtobrutinib

Also known as 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(2S)-1,1,1-trifluoropropan-2-yl]pyrazole-4-carboxamide

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations· Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models· Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM

ChemicalCAS2101700-15-4MW479.43FormulaC22H21F4N5O3
CAS number
2101700-15-4
Molecular weight
479.43
Formula
C22H21F4N5O3
Solubility
DMSO ： 50 mg/mL (104·29 mM; Need ultrasonic)
InChIKey
FWZAWAUZXYCBKZ-NSHDSACASA-N
Catalogue number
GC62515
Brand
GLPBIO
Computed properties PubChem CID 129269915 · XLogP 3.3 · TPSA 125 Ų · H-bond donors 3
XLogP
3.3
TPSA
125 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
7
Heavy atoms
34

SMILES C[C@@H](C(F)(F)F)N1C(=C(C(=N1)C2=CC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)F)OC)C(=O)N)N

Computed descriptors from PubChem (CID 129269915), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.