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Chemical structure of KS15

GC62472

KS15

Also known as (2R)-3-[3-[(E)-N-[(4-bromophenyl)methoxy]-C-methylcarbonimidoyl]phenyl]-2-ethoxypropanoic acid

KS15 is an inhibitor of the interactions between cryptochromes (CRYs: CRY1 and CRY2) and the CLOCK:BMAL1 heterodimer· KS15 impairs the feedback actions of CRYs on E-box-dependent transcription (EC50=4·9 μM) by CLOCK:BMAL1 heterodimer, an indispensable transcriptional regulator of the mammalian circadian clock· Anti-proliferative activity

ChemicalCAS1033781-20-2MW420.3FormulaC20H22BrNO4
CAS number
1033781-20-2
Molecular weight
420.3
Formula
C20H22BrNO4
Solubility
DMSO : 100 mg/mL (237·93 mM; Need ultrasonic)|Water : < 0·1 mg/mL (insoluble)
InChIKey
GWSVRVKPZVYTCS-VZMFNRANSA-N
Catalogue number
GC62472
Brand
GLPBIO
Computed properties PubChem CID 25114872 · XLogP 4.5 · TPSA 68.1 Ų · H-bond donors 1
XLogP
4.5
TPSA
68.1 Ų
H-bond donors
1
H-bond acceptors
5
Rotatable bonds
9
Heavy atoms
26

SMILES CCO[C@H](CC1=CC(=CC=C1)/C(=N/OCC2=CC=C(C=C2)Br)/C)C(=O)O

Computed descriptors from PubChem (CID 25114872), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.