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Chemical structure of LCAHA

GC62460

LCAHA

Also known as (4R)-N-hydroxy-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanamide

LCAHA (LCA hydroxyamide) is a deubiquitinase USP2a inhibitor with IC50s of 9·7 μM and 3·7μM in Ub-AMC Assay and Di-Ub Assay, respectively· LCAHA destabilizes Cyclin D1 and induces G0/G1 arrest by inhibiting deubiquitinase USP2a

ChemicalCAS117094-40-3MW391.59FormulaC24H41NO3
CAS number
117094-40-3
Molecular weight
391.59
Formula
C24H41NO3
InChIKey
WZXAGWREMCSWMF-HVATVPOCSA-N
Catalogue number
GC62460
Brand
GLPBIO
Computed properties PubChem CID 126961696 · XLogP 5.5 · TPSA 69.6 Ų · H-bond donors 3
XLogP
5.5
TPSA
69.6 Ų
H-bond donors
3
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
28

SMILES C[C@H](CCC(=O)NO)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)C

Computed descriptors from PubChem (CID 126961696), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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