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Chemical structure of (S)-PI3Kα-IN-4

GC62450

(S)-PI3Kα-IN-4

Also known as (2S)-3-[6-[5-[(2-chloro-4-fluorophenyl)sulfonylamino]-6-methoxy-3-pyridinyl]-4-oxoquinazolin-3-yl]-N,2-dimethylpropanamide

(S)-PI3Kα-IN-4 is a potent inhibitor of PI3Kα, with an IC50 of 2·3 nM· (S)-PI3Kα-IN-4 shows 38·3-, 4·25-, and 4·93-fold selectivity for PI3Kα over PI3Kβ, PI3Kδ, and PI3Kγ, respectively· (S)-PI3Kα-IN-4 can be used for the research of cancer

ChemicalCAS2322293-84-3MW560FormulaC25H23ClFN5O5S
CAS number
2322293-84-3
Molecular weight
560
Formula
C25H23ClFN5O5S
InChIKey
LPATWVFSBNDSHR-AWEZNQCLSA-N
Catalogue number
GC62450
Brand
GLPBIO
Computed properties PubChem CID 155129768 · XLogP 2.8 · TPSA 138 Ų · H-bond donors 2
XLogP
2.8
TPSA
138 Ų
H-bond donors
2
H-bond acceptors
9
Rotatable bonds
8
Heavy atoms
38

SMILES C[C@@H](CN1C=NC2=C(C1=O)C=C(C=C2)C3=CC(=C(N=C3)OC)NS(=O)(=O)C4=C(C=C(C=C4)F)Cl)C(=O)NC

Computed descriptors from PubChem (CID 155129768), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
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Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.