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Chemical structure of AKI603

GC62433

AKI603

Also known as 6-(4-methylpiperazin-1-yl)-4-N-(5-methyl-1H-pyrazol-3-yl)-2-N-(4-nitrophenyl)pyrimidine-2,4-diamine

AKI603 is an inhibitor of Aurora kinase A (AurA), with an IC50 of 12·3 nM· AKI603 is developed to overcome resistance mediated by BCR-ABL-T315I mutation· AKI603 exhibits strong anti-proliferative activity in leukemic cells

ChemicalCAS1432515-73-5MW409.45FormulaC19H23N9O2
CAS number
1432515-73-5
Molecular weight
409.45
Formula
C19H23N9O2
Solubility
DMSO ： 125 mg/mL (305·29 mM; Need ultrasonic)
InChIKey
UNKOUVAYOLLXER-UHFFFAOYSA-N
Catalogue number
GC62433
Brand
GLPBIO
Computed properties PubChem CID 72194397 · XLogP 3.1 · TPSA 131 Ų · H-bond donors 3
XLogP
3.1
TPSA
131 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
5
Heavy atoms
30

SMILES CC1=CC(=NN1)NC2=CC(=NC(=N2)NC3=CC=C(C=C3)[N+](=O)[O-])N4CCN(CC4)C

Computed descriptors from PubChem (CID 72194397), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.