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Chemical structure of Thailanstatin A

GC62288

Thailanstatin A

Also known as 2-[(3R,4R,5R,7S)-5-[(1E,3E)-5-[(2S,3S,5R,6R)-5-[[(Z,4S)-4-acetyloxypent-2-enoyl]amino]-3,6-dimethyloxan-2-yl]-3-methylpenta-1,3-dienyl]-4-hydroxy-1,6-dioxaspiro[2.5]octan-7-yl]acetic acid

Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50=650 nM)· Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC50s against multiple cancer cell lines· Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC

ChemicalCAS1426953-21-0MW535.63FormulaC28H41NO9
CAS number
1426953-21-0
Molecular weight
535.63
Formula
C28H41NO9
Solubility
DMSO ： 250 mg/mL (466·74 mM; Need ultrasonic)
InChIKey
GJKQDOMCDFJANR-FUDLAKRJSA-N
Catalogue number
GC62288
Brand
GLPBIO
Computed properties PubChem CID 71665768 · XLogP 1.9 · TPSA 144 Ų · H-bond donors 3
XLogP
1.9
TPSA
144 Ų
H-bond donors
3
H-bond acceptors
9
Rotatable bonds
11
Heavy atoms
38

SMILES C[C@H]1C[C@H]([C@H](O[C@H]1C/C=C(\C)/C=C/[C@@H]2[C@H]([C@@]3(C[C@H](O2)CC(=O)O)CO3)O)C)NC(=O)/C=C\[C@H](C)OC(=O)C

Computed descriptors from PubChem (CID 71665768), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

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