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Chemical structure of SYN1143

GC62268

SYN1143

Also known as N-[3-fluoro-4-(7-methoxyquinolin-4-yl)oxyphenyl]-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenylpyrazole-4-carboxamide

SYN1143 is a potent, selective and orally active dual inhibitor of c-Met/RON, with IC50s of 4 and 9 nM, respectively· SYN1143 has weak inhibitory activity on Lck, Tie2, Src, and BTK with IC50s ranging from 160 to 710 nM· SYN1143 can be used for the research of cancers that RON and c-Met are activated

ChemicalCAS913376-84-8MW556.58FormulaC31H29FN4O5
CAS number
913376-84-8
Molecular weight
556.58
Formula
C31H29FN4O5
Solubility
DMSO ： 100 mg/mL (179·67 mM; Need ultrasonic)
InChIKey
UYMSIPINLJNNOU-UHFFFAOYSA-N
Catalogue number
GC62268
Brand
GLPBIO
Computed properties PubChem CID 16757524 · XLogP 4.8 · TPSA 104 Ų · H-bond donors 2
XLogP
4.8
TPSA
104 Ų
H-bond donors
2
H-bond acceptors
8
Rotatable bonds
8
Heavy atoms
41

SMILES CC1=C(C(=O)N(N1CC(C)(C)O)C2=CC=CC=C2)C(=O)NC3=CC(=C(C=C3)OC4=C5C=CC(=CC5=NC=C4)OC)F

Computed descriptors from PubChem (CID 16757524), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

Ordering in Israel

Lead time
Ships from the manufacturer to your lab in 8–14 business days; customs and cold chain handled by LABO Scientific.
Pricing
Quoted in ILS, excl. VAT. Add the item to your quote and we confirm the final price, usually the same business day.
Documents
Lot certificate of analysis and manufacturer SDS are emailed with your order confirmation.
Who we serve
Universities, hospitals and biotech companies across Israel. Research use only — not for diagnostic or therapeutic use.