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Chemical structure of MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

GC62264

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH

Also known as 2-[[[2-[[(2S)-2-[[2-[[2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]methoxy]acetic acid

MC-Gly-Gly-Phe-Gly-NH-CH2-O-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)

ChemicalCAS1599440-25-1MW616.62FormulaC28H36N6O10
CAS number
1599440-25-1
Molecular weight
616.62
Formula
C28H36N6O10
Solubility
DMSO : 120 mg/mL (194·61 mM; Need ultrasonic)
InChIKey
SODPQQOBNODMSG-FQEVSTJZSA-N
Catalogue number
GC62264
Brand
GLPBIO
Computed properties PubChem CID 118305142 · XLogP -1.3 · TPSA 229 Ų · H-bond donors 6
XLogP
-1.3
TPSA
229 Ų
H-bond donors
6
H-bond acceptors
10
Rotatable bonds
20
Heavy atoms
44

SMILES C1=CC=C(C=C1)C[C@@H](C(=O)NCC(=O)NCOCC(=O)O)NC(=O)CNC(=O)CNC(=O)CCCCCN2C(=O)C=CC2=O

Computed descriptors from PubChem (CID 118305142), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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