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Chemical structure of 2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

GC62233

2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

Also known as 2,6-dichloro-N-[2-(cyclopropanecarbonylamino)-4-pyridinyl]benzamide

GDC-046 is a potent, selective, and orally bioavailable TYK2 inhibitor with Kis of 4·8, 0·7, 0·7, and 0·4 nM for TYK2, JAK1, JAK2, and JAK3, respectively

ChemicalCAS1258292-64-6MW350.2FormulaC16H13Cl2N3O2
CAS number
1258292-64-6
Molecular weight
350.2
Formula
C16H13Cl2N3O2
Solubility
DMSO ： 62·5 mg/mL (178·47 mM; Need ultrasonic)
InChIKey
IAFNAEGXTKTGHN-UHFFFAOYSA-N
Catalogue number
GC62233
Brand
GLPBIO
Computed properties PubChem CID 49839561 · XLogP 2.9 · TPSA 71.1 Ų · H-bond donors 2
XLogP
2.9
TPSA
71.1 Ų
H-bond donors
2
H-bond acceptors
3
Rotatable bonds
4
Heavy atoms
23

SMILES C1CC1C(=O)NC2=NC=CC(=C2)NC(=O)C3=C(C=CC=C3Cl)Cl

Computed descriptors from PubChem (CID 49839561), public domain. Identity cross-checked against the supplier's molecular formula and weight — verify before use.

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